Erhaltungstherapie mit Methadontabletten - Eine Übersicht

Erhaltungstherapie mit Methadontabletten - Eine Übersicht

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Methadone is contraindicated rein patients with a known hypersensitivity to methadone hydrochloride or any other ingredient hinein methadone hydrochloride tablets.

Addiction and misuse warning: Methadone comes with a risk of addiction even when it’s used the right way. This can lead to drug misuse. Having an addiction to and misusing this drug can increase your risk of overdose and death.

Since the metabolism of methadone is mediated primarily by CYP3A4 isozyme, coadministration of drugs that inhibit CYP3A4 activity may cause decreased clearance of methadone. The expected clinical results would Beryllium increased or prolonged opioid effects. Thus, methadone-treated patients coadministered strong inhibitors of CYP3A4, such as azole antifungal agents (e.

Methadone should Beryllium used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Abuse and addiction are separate and distinct from physical dependence and tolerance. Physicians should Beryllium aware that addiction may not be accompanied by concurrent tolerance and symptoms of physical dependence rein all addicts. Hinein addition, abuse of opioids can occur rein the absence of true addiction and is characterized by misuse for non-medical purposes, often in combination with other psychoactive substances.

Overdose hinein children warning: Children Weltgesundheitsorganisation accidentally take this drug have a high risk of death from overdosing. Children should not take this drug.

Upon discontinuation of phenytoin, the incidence of withdrawal symptoms decreased and methadone exposure increased to a level comparable to that prior to phenytoin administration.

Pediatric – The pharmacokinetics of methadone have not been evaluated in the pediatric Individuenbestand.

Increased side effects from other drugs: Taking methadone with certain medications raises your risk of side effects from those drugs. Examples of these drugs include:

Tolerance is the need for increasing doses of opioids to maintain a defined effect such as analgesia (rein the absence of disease progression or other external factors).

Rein Methadontabletten ohne Rezept online these patients, even usual therapeutic doses of methadone may decrease respiratory drive while simultaneously increasing airway resistance to the point of apnea. Alternative, non-opioid analgesics should Beryllium considered, and methadone should be used at the lowest effective dose and only under careful medical supervision.

Anxiety – Since methadone as used by tolerant patients at a constant maintenance dosage does not act as a tranquilizer, patients Weltgesundheitsorganisation are maintained on this drug will react to life problems and stresses with the same symptoms of anxiety as do other individuals.

The respiratory depressant effects of opioids and their capacity to elevate cerebrospinal-fluid pressure may be markedly exaggerated hinein the presence of head injury, other intracranial lesions or a pre-existing increase in intracranial pressure.

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